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- Question: My 18-yr-old daughter was diagnosed in Nov. 03 (then 15) with PXA brain tumor (gr II). The surgery was successful with near total resection. No further treatment administered other than Trileptal for seizures. An MRI in Mar. 06 revealed substantial regrowth (5cm x 4cm) in the same area, surgery followed and the mass was diagnosed as GBM & Anaplastic PXA (from 2 different institutions). Treatment was 6 weeks of radiation and Temodar simultaniously plus 6 rounds of 5/23 Temodar. In the middle of treatment, an MRI revealed a significant mass (in Jul. 06) but this was thought to be necrosis from radiation rather than tumor; MRI in Oct. 06 revealed the same. PET scan concluded mass to be tumor, 3rd craniotomy in Nov. 06, mass diagnosed as PXA with radiation damage, surgeons unable to remove about 1 cm of tumor. She completed the rounds of Temodar and is now scheduled for an MRI at the end of Jan. 07. If the tumor is stable she will stop Temodar and will be followed up with serial MRIs. Finally my question, is there a clinical trial for her type of tumor/situation if Temodar stops working and, if so, is it possible that it can be administered from another location?
Yes, there should be many Phase 2 and Phase 1 studies available at the major
brain tumor treatment centers.
You might benefit from information on the www.virtualtrials.com website
and the books on www.survivingbraincancer.com in finding those centers that
have these clinical trials.