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Trials and Noteworthy Treatments

  Treatment Location Last Updated
Details CERN 09-02: Phase II trial of carboplatin and bevacizumab for the treatment of recurrent low-grade and anaplastic supratentorial, infratentorial and spinal cord ependymoma in adults Houston, TX 05/11/2011
Details 2006-0709: Phase I / II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Carboplatin in Adults with Recurrent Glioblastoma Multiforme Houston, TX 03/30/2010
Details 2009-0651: Phase I/II adaptive randomized trial of vorinostat, erlotinib and carboplatin in adults with recurrent glioblastoma Houston, TX 03/29/2010
Details A Phase I/II Study of Patients with Newly Diagnosed Primary Central Nervous System Lymphoma Treated with Methotrexate/BBBD, and Adding Rituximab (an anti CD-20 Antibody) and Carboplatin to the Treatment Regimen Cincinnati, OH 12/02/2009
Details Phase I/II Study of Carboplatin, Melphalan and Etoposide Phosphate in Conjunction with Osmotic Opening of the Blood-Brain Barrier and Delayed Intravenous Sodium Thiosulfate Chemoprotection, in Subjects with Anaplastic Oligodendroglioma or Oligoastrocytoma Cincinnati, OH 12/02/2009
Details Phase II Clinical Trial of Patients with High-Grade Glioma Treated with Intra-arterial Carboplatin-based Chemotherapy, Randomized to Treatment with or without Delayed Intravenous Sodium Thiosulfate as a Potential Chemoprotectant against Severe Thrombocytopenia Cincinnati, OH 12/02/2009
Details A Phase I Trial of Enzastaurin (LY317615) in Combination With Carboplatin in Adults With Recurrent Gliomas Bethesda, MD 04/22/2009
Details Phase I/II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Carboplatin in Adults With Recurrent Glioblastoma Multiforme Houston , TX 04/27/2008
Details A Phase II Pilot Trial of Radiation Therapy With Concurrent and Adjuvant Temozolomide, Tamoxifen and Carboplatin (T2C) in the Treatment of Patients With Primary Central Nervous System Malignant Gliomas Vista, CA 08/20/2007
Details Phase II Randomized Study of Intra-Arterial Carboplatin, Cyclophosphamide, and Etoposide or Etoposide Phosphate With or Without Delayed High-Dose Sodium Thiosulfate in Patients With High-Grade Glioma Cleveland, OH
Columbus, OH
Portland, OR
05/01/2007
Details Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Portland, OR 11/27/2005
Details Intra-arterial carboplatin for supratentorial brain tumors Fort Worth, TX 11/26/2005
Details Thalomidâ„¢ and Carboplatin for the Treatment of Pediatric Brain Stem Glioma Baltimore, MD
Minneapolis, MN
St. Paul, MN
Dayton, OH
11/26/2005


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  (0.7967)   My father was diagnosed with a GBM in March, 2006. He had a resection followed with standard radiation and Temodar. Recurrent tumor in June, 2006, and moved treatment to MD Anderson in Houston. Resection and inclusion in clinical trial of Carboplatin IV infusion once per month and Tarceva for 28 days. His tumor showed on CAT scan around July 8 (2 weeks after sugery) but we were not informed. It was 4 cm at the time, and now is 5 cm. We discovered the tumor was back due to seizures. He has an appointment with Dr. Levin at MDACC to discuss Accutane. Any other treatments we should discuss or learn about?

  (0.7967)   I was diagnosed in 2002 with lung cancer; I received Carboplatin/Taxol, chest radiation and a wedge resection. I was recently found to have a cerebellum lesion which was surgically removed. I have conflicting recommendations and am wondering how best to make a decision. One recommendation is to wait for a scan result and go with treatment according to that. My oncologist is recommending whole brain radiation with Temodar. My recent PET scan was clear and the MRI only showed the one metastasis.

  (0.7967)   My son is three years old and has just finished 11 months of a 15-month Carboplatin/Vincristine protocol for an Optic Glioma. The tumor has regressed, but the reason he had to quit chemotherapy is he developed first cold antibodies, then warm. His hgb dropped to 4.6, and he could not be transfused because no perfect match was found. His hgb is now 12.1 (after 4 weeks of prednisone). My question to you is: do you have any information on patients who have an OG and have had to end chemo early? Are the chance of recurrence higher than with patients who complete chemo? I am running out of places to ask; no one has answers! We are being treated at the Boman Grey School of Medicine (Wake Forest/Baptist in Winston-Salem NC.)

  (0.7742)   My son finished his second protocol of chemotherapy (procarbazine, thioguanine, CCNU and vincristine) in Feb. 2005. His first chemotherapy protocol was Carboplatin and Vincristine for 12 months ending in early 2003. Both protocols showed initial shrinkage and then stability; however, his dosages were reduced in protocol II due sometimes to low counts. Sometimes his oral dosage was too much for his system and he was sick, not allowing the full dosages to be consumed. We do not know if he was able to get the full effect of the second protocol. The Grade II Fibrilary Thalamic Astrocytoma that is currently stable in the right peduncle measures approximately 2.3 cm by 2.3 cm by 2.0 cm. What do you suggest other than waiting for it to grow and then consider another chemotherapy regimen at that time. He has not yet had any radiation of any type, but is functioning well.

  (0.7742)   Oligo II with no 1P/19Q deletions...radiation has been ruled out already. How would a neuro-oncologist handle the chemo process with the no deletion results? Also, what are the odds/past results that some typye of chemo would work?

  (0.7742)   My 4-year-old daughter, Erin, was diagnosed on 8-11-02 with a Diffuse Pontine Glioma. She immediately was enrolled in a clinical trial by her doctor, at Children~s Memorial Hospital. This trial uses Carboplatin monthly and Thalidomide daily as well as radiation therapy. She has undergone about 14 sessions of radiation directly to her pons tumor. She has responded very well. We know this because another MRI was performed on her brain on 8-27-02. Based on her complaints of occasional back pain, her doctor ordered a spinal MRI. This MRI showed new tumor growth (very early) in the cervical spine area. He performed a spinal tap yesterday and feels the tumor cells are PNET. It has been decided to now include the entire brain, brain stem and spine in the radiation treatment. She will begin this new radiation regimen beginning Tuesday, September 10th. Her chemotherapy regimen will also be changed to 3 chemotherapy drugs that are proven to be somewhat effective with PNET tumors. I understand how rare this occurance is. Erin is otherwise very healthy. We were told that her diagnosis has occurred early in her disease. My question to you is: do you have any knowledge of any other children with PNET pontine gliomas that also had secondary cervical tumors, that were diagnosed very early and received radiation and chemotherapy. If so, how were they treated and what was the outcome.





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