Details For Selected Brain Tumor Treatment
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Treatment Name: Phase I/II Studies of BAY 43-9006 (Sorafenib) in Combination With OSI-774 (Erlotinib), R115777 (Tipifarnib) or CCI-779 (Temsirolimus) in Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma
Phase: Phase 1/2
Treatment ID#: 1805         NABTC 05-02
Age Group: Adults Only
Min Karnofsky Score: 60: Requires occasional assistance but is able to care for most of own needs
Conditions: Prior Surgery is Allowed
Prior Radiation is Allowed
Prior Chemotherapy is Allowed
Recurrent Glioblastoma Multiforme or Gliosarcoma
Last Updated: 04/15/2008
Tumor Types: Glioblastoma Multiforme
Gliosarcoma
Comments: BAY 43-9006 (sorafenib) blocks the vascular endothelial growth factor receptor (VEGF-R) and a protein in an important tumor growth pathway (B-raf). CCI-779 (temsirolimus) blocks a specific protein, mTOR, which is important in pathways that promote tumor growth. R115777 (tipifarnib) blocks an important process called farnesylation that activates proteins for several important tumor growth pathways. OSI-774 (erlotinib) blocks the epidermal growth factor receptor (EGF-R). Combining two drugs that block these factors and receptors may provide better tumor control than a single drug. This study will also determine the relationship between biomarkers in the tumor and patient`s blood with patient response.
Treatment Type: Less-Toxics
Immunological, Biological or Targeted Therapy
Contact: David Reardon MD
The Brain Tumor Center at Duke
Rm 047 Baker House, Hospital South
Trent Drive
Durham, NC 27710 USA
Phone: (919)684-5301
Fax: (919)684-6674
E-mail: reard003@mc.duke.edu
Website: www.cancer.duke.edu/btc
  • Last updated refers to the date when our listing for each treatment was last updated.
  • ID is a combination of our internal ID and the official ID for the trial, if any.
  • Min Karnofsky is a general guide to how well you have to function to use this treatment


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