Details For Selected Brain Tumor Treatment

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Last updated refers to the date when our listing for each treatment was last updated.
ID is our internal ID - starting with VT.
Min Karnofsky is a general guide to how well you have to function to use this treatment
For trials that also have a NCT number, you can click that number to pop up the listing from the clinicaltrials.gov website.

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		Treatment Name:		A Phase II Trial of Thalidomide in combination with Temozolomide or CPT-11 in patients with recurrent anaplastic gliomas or glioblastoma multiforme

		Keywords:		Thalidomide, CPT-11, Temozolomide

		Phase:		Phase 2

		Treatment ID#s:		VT1855 DM02-595

		Age Group:		Adult And Pediatric

		Min Karnofsky Score:		70: Cares for self, unable to perform normal activity or to do active work

		Conditions:		Newly Diagnosed: N Recurrent: Y Prior Surgery is Allowed Prior Radiation is Allowed Prior Chemotherapy is Allowed Recurrent Glioblastoma, Gliosarcoma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Mixed Anaplastic Glioma

		Last Updated:		10/27/2008

		Tumor Types:		Anaplastic Astrocytoma Glioblastoma Multiforme Gliosarcoma Mixed Glioma Oligodendroglioma High Grade Pediatric Brain Tumors


		Comments:		The combination of cytotoxic and antiangiogenic drugs may challenge tumor cells by two distinct but interdependent biological mechanisms. This trial uses two DNA damaging agents with differing mechanisms of action - Temozolomide (alkylator) and CPT-11 (topoisomerase I inhibitor) in combination with Thalidomide against recurrent gliomas. The non-overlapping toxicities of these agents and thalidomide can be expected to limit the toxicity of the combinations.

		Treatment Type:		Chemotherapy Less-Toxics Immunological, Biological or Targeted Therapy.

		Contact:		MD Anderson Cancer Center Jan Esenwein Program Coordinator, Brain Tumor Program Contact: Jan Esenwein or Marie Woodward 1515 Holcombe Blvd Houston, TX 77030- Phone:(713)745-2264 Fax: (713)794-4999 Click here to send an email Website: www.mdanderson.org/diseases/braincancer/

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