Clinical Trial Details
Braintumor Website

[Information provided by:, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT01985750 : Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception
PhasePhase 0
AgesMin: 45 Years Max: 85 Years
Inclusion Criteria:

- Males and females with chronic lung disease, aged between 45 and 85 years old who
have been referred for pulmonary rehabilitation.

- The subject is able and willing to give fully informed consent.

Exclusion Criteria:

Any of the commonly accepted contraindications to MRI scanning, for example, severe
claustrophobia, presence of metallic implants, a pacemaker etc.

- Pregnancy. The risk to foetus of radiofrequency energy of the MRI scan is unknown.

- Inadequate understanding of verbal and written information in English, sufficient to
complete an MRI safety screening.

- Unable to lie flat and still for 1/2 hour

- Requirements for oxygen therapy

- Significant cardiac, neurological, psychiatric or metabolic disease

- Contra-indications to d-cycloserine: Alcoholism, known hypersensitivity, severe renal

- Regular therapy with prescribed opioid analgesics

- Antidepressant therapy (this may alter hippocampal plasticity)

- Previous pulmonary rehabilitation (because the learning may be different on repeat
pulmonary rehabilitation treatments)
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