Clinical Trial Details
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NCT02742883 : A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG)
PhasePhase 2
AgesMin: 3 Months Max: 70 Years
Inclusion Criteria:

Five cohorts of patients with diffuse, intrinsic pontine glioma will be studied:

1. Patients age 3 months to < 3 years;

2. Patients age 3-21 years with progressive disease (PD) following radiation therapy
(RT) ± chemotherapy and/or other therapies;

3. Patients age 3-21 years with newly diagnosed DIPG who (or whose parents / guardians)
have refused RT;

4. Patients age > 21 years with PD following RT ± chemotherapy and/or other therapies;

5. Patients age > 21 years with newly diagnosed DIPG who have refused RT.

Exclusion Criteria include:

1. Disseminated disease, multicentric tumors, or leptomeningeal disease;

2. Uncontrolled intercurrent illness;

3. A history of New York Heart Association Class II congestive heart failure or above;

4. Pregnancy.
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