Clinical Trial Details
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NCT02893553 : The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
PhasePhase 2
AgesMin: 18 Years Max: 85 Years
Inclusion Criteria:

Spinal Cord Injured

- Any level of injury

- Any ASIA grade of SCI

- Primarily wheelchair dependent for mobility

- Duration of injury ? 1 year

Exclusion Criteria:

- Current illness or infection

- History of severe autonomic dysreflexia (AD: condition where BP increases)

- More than 3 symptomatic events per week; BP elevations above 140/90 mmHg; adverse
symptoms reporting (e.g., light headedness, dizziness, goosebumps, chills, nausea,

- Diagnosis of hypertension

- History of Traumatic Brain Injury (TBI)

- Documented history of traumatic brain injury (TBI)

- Neurological condition other than SCI (Alzheimer's disease, dementia, stroke,
multiple sclerosis, Parkinson's disease, etc)

- History of epilepsy or other seizure disorder

- Liver or kidney disease

- Bladder problems including blockage of the urine and/or weak urine stream

- Diagnosis of a psychiatric disorder such as schizophrenia or bipolar disorder

- Diagnosis of artery disease, heart failure, irregular heartbeat, and AV block

- Allergies to aspirin, a yellow dye, pyridostigmine bromide, midodrine hydrochloride,
lyethylene oxide, polyethylene glycol, hydroxypropyl cellulose, butylated
hydroxytoluene, magnesium stearate, hypromellose, yellow ferric oxide, and red ferric

- Had major surgery in the last 30 days

- Illicit drug abuse within the last 6 months

- Pregnant
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