Clinical Trial Details
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[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT00001238 : Clinical Manifestations and Molecular Bases of Heritable Urologic Malignant Disorders
PhaseN/A
AgesMin: 2 Years Max: N/A
Eligibility
- INCLUSION CRITERIA - Subject Category A:

Category A will include patients, and relatives, who may or may not be affected who will
be evaluated in the Warren G. Magnuson Clinical Center. Patients in this category will be
eligible if they or their family members manifest one or more of the following features in
a pattern suggestive of a heritable urologic malignant disorder:

- One or more histologically proven or suspected renal carcinomas and/or cysts

- Cerebellar, spinal, medullary or cerebral hemangioblastomas

- Retinal angioma

Pancreatic neuro-endocrine carcinoma, microcystadenoma and/or cysts

- Pheochromocytoma

- Papillary cystadenoma of the epididymis or broad ligament

- Endolymphatic sac tumor

- Known or suspected cutaneous fibrofolliculomas or multiple skin-colored papules

- History of spontaneous pneumothorax

- Lung cysts

- Thyroid carcinoma

- Intestinal polyposis + / - colon cancer

- Cutaneous or Uterine leiomyoma or uterine leiomyosarcoma, sarcoma

INCLUSION CRITERIA - Subject Category B:

Category B will include patients, their at-risk relatives and spouses of patients with
inherited urologic malignancies with the above listed clinical findings who live at a
distance and who will not be evaluated at the Clinical Center. In some cases, local
diagnostic testing may be necessary for these individuals in addition to collection of a
blood sample for molecular analysis.

INCLUSION CRITERIA - Subject Category C:

Category C will include relatives and spouses who enroll in this study primarily for
genetic linkage studies. These individuals will contribute a blood sample for DNA analysis
only. No imaging diagnostic testing will be performed on individuals from this category.

EXCLUSION CRITERIA:

Persons unable to give informed consent.
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT00001238      |      Link to official Clinicaltrials.gov listing
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