Clinical Trial Details
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NCT00054756 : Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities
PhasePhase 2
AgesMin: 2 Years Max: 65 Years

Inclusion Criteria:

-All adults and children requiring dynamic testing of the hypothalamic-pituitary axis for
the evaluation of pituitary reserve, inconsistent thyroid function test, inappropriate TSH
secretion, or pre-and post-operative evaluation of pituitary adenomas (glycoprotein
hormone secreting tumors, growth hormone secreting tumors and TSH secreting tumors).

Exclusion Criteria:

- Uncontrolled hypertension;

- Uncontrolled seizure disorder;

- Unstable coronary disease;

- Known allergy to TRH.


-TRH is available for use in other IRB approved research protocols either using the
standard diagnostic testing protocol or the modified TRH test.

Exclusion Criteria:

- Untreated hypertension;

- Coronary artery disease;

- History of asthma;

- History of seizures;

- Pregnancy;

- Known allergy to TRH.
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