Clinical Trial Details
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NCT00946673 : Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer
PhasePhase 1
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- All patients age 18 years and older with histologically proven non-small cell lung
cancer and 1-4 brain metastases, each measuring less than 2 cm will be eligible.
Prior surgery or radiation is allowed as long as the target metastatic lesion(s) has
not been treated with previous radiation.

- Adequate organ function (section 3.1.10).

- ECOG performance status 0-2.

- Life expectancy of >=12 weeks.

- Systemic chemotherapy washout period >=7 days.

Exclusion Criteria:

Patients who have previously been treated with whole brain irradiation, pediatric patients
(age <18), pregnant women, and patients who are unable to give informed consent.
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