Clinical Trial Details
Braintumor Website

[Information provided by:, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT01301391 : Study Of Oral PHA-848125AC In Patients With Malignant Thymoma Previously Treated With Multiple Lines Of Chemotherapy
PhasePhase 2
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- Signed and dated IRB/Approved Informed Consent

- Histologically or cytologically proven diagnosis of unresectable B3 thymoma or thymic
carcinoma recurrent or progressing after more than one prior systemic therapy for
advanced / metastatic disease

- Presence of measurable disease

- Age >=18 years old

- ECOG performance status 0-1

- Negative pregnancy test (if female in reproductive years)

- Use of effective contraceptive methods if men and women of child producing potential

- Adequate liver function Total Serum Bilirubin <=1.5 x upper limit of normal (ULN)
Transaminases (AST/ALT) <=2.5ULN (if liver metastases are present, then <=5ULN is
allowed) ALP <=2.5ULN (if liver and/or bone metastases are present, then <=5ULN is

- Adequate renal function Serum Creatinine <=ULN or Creatinine Clearance calculated by
Cockcroft and Gault's formula > 60 mL/min

- Adequate hematologic status ANC >=1,500cells/mm3 Platelet Count >= 100,000cells/mm3
Hemoglobin >=9.0g/dL

- Two weeks must have elapsed since completion of prior chemotherapy, minor surgery,
radiotherapy (provided that no more than 25% of bone marrow reserve has been

- Resolution of all acute toxic effects of any prior treatments to NCI CTC (Version
3.0) grade <=1

Exclusion Criteria:

- Any of the following in the past 6 months: myocardial infarction, uncontrolled
cardiac arrhythmia, unstable angina, coronary/peripheral artery bypass graft,
symptomatic congestive heart failure, cerebrovascular accident or transient ischemic
attack, pulmonary embolism, deep vein thrombosis

- Grade >1 retinopathy

- Known brain metastases

- Known active infections

- Pregnant or breast feeding women

- Diabetes mellitus uncontrolled

- Gastrointestinal disease that would impact on drug absorption

- Patients under treatment with anticoagulants or with coagulation disorders or with
signs of hemorrhage at baseline

- Patients with previous history or current presence of neurological disorders (with
the exception of myasthenia gravis), including epilepsy (although controlled by
anticonvulsant therapy), Parkinson's disease and extra-pyramidal syndromes.

- Other severe acute or chronic medical or psychiatric condition or laboratory
abnormality that make the patient inappropriate for entry into this study
LinksPermanent Link to THIS page:      |      Link to official listing

Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2020 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557