Clinical Trial Details
Braintumor Website

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NCT01364792 : To Rescue Cognition With Valaciclovir
PhasePhase 2
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- Age above 18

- Written informed consent for participation

- Diagnosis: schizophrenia, all subtypes (DSM-IV 295.xx)

- Psychosis, characterised by a total score on the positive scale on the PANSS above
14. In addition, a minimal score of 4 or more on an item of the positive scale.

Exclusion Criteria:

- The use of benzodiazepines. Benzodiazepines have affinity for the peripheral
benzodiazepine receptor which is the target receptor for [11C]-PK11195 PET and they
can thus interfere with the PET study.

- The use of a nonsteroidal antiinflammatory drug or paracetamol in week before the PET
scans and during the treatment of valaciclovir

- The use of anticoagulants or having coagulation disorder

- Use of somatic medication which may affect the immune system (e.g. corticoids,
anti-inflammatory drugs, immune suppressive drugs)

- Use of any investigational drug

- Current or recent (<1 year) alcohol or substance abuse

- Disturbed kidney function

- Disturbed liver function

- Current or recent (<4 weeks) infectious or inflammatory disease

- Current systemic disease

- Major metabolic disease (diabetes, hyper- or hypothyroidism, Cushing disease or
Addison disease)

- Somatic, organic or neurological disorder

- Participation in a scientific research study (<1 year) involving radiation

- Claustrophobia

- Presence of materials in the body that can be magnetized, like:

- A pacemaker

- Metal fragments

- Shunts

- Artificial heart valves

- Vascular clips

- Fixed hearing aid

- Tattoos containing metal

- Hair implants

- Artificial dentures
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