Clinical Trial Details
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NCT01410370 : Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases
PhasePhase 2
AgesMin: 18 Years Max: 75 Years
Inclusion Criteria:

- Histologically confirmed malignancy with presence of intraparenchymal brain

- Karnofsky performance status ? 40

- Measurable disease according to RECIST criteria

- Hematologic function: WBC ? 4.0×109/L, PLT ? 80×109/L, Hb ? 90g/L

- Renal function: Cr ? 2.0×ULN

- Hepatic function: BIL ? 2.0×ULN, ALT/AST ? 5.0×ULN

- Adequate cardiac function

- Life expectancy ? 3 months

Exclusion Criteria:

- Evidence of bleeding diathesis or serious infection

- Serious cardiovascular disease (congestive heart failure, uncontrollable arrhythmia,
unstable angina, myocardial infarction, serious heart valve disease, resistant

- Uncontrollable mental and nervous disorders

- Pregnant or lactating women
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