Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT01514877 : Icotinib Combined With Whole Brain Radiotherapy in Treating Multiple Brain Metastases From Non-Small Cell Lung Cancer
PhasePhase 2
AgesMin: 18 Years Max: 75 Years
Eligibility
Inclusion Criteria:

- Cytologic or histological diagnosis of non-small cell lung cancer

- Patients with disease progression after systemic chemotherapy with two-drug
combination regimens that includes a platinum agent or patients with EGFR mutation
status who have not been treated

- Patients are diagnosed with multiple brain metastases for the first time in 4 weeks

- Diagnosis of brain metastases is made based on Magnetic resonance imaging (MRI).

- Doctors consider the patient will benefit from WBRT

- No prior brain radiotherapy

- ECOG performance status 0-2

- age:18-75 years

- Neutrophil count ?1.5×10 to the 9th power/L and platelets?100×10 to the 9th power/L.
hemoglobin ?90 g/L

- Hepatic: total bilirubin less than or equal to 1.5 times upper limit of normal (ULN)
Alanine transaminase (ALT) and aspartate transaminase (AST) less than or equal to 2.5
times ULN (or less than or equal to 5 times ULN in case of known liver involvement)

- Renal: Serum Creatinine less than or equal to 1.5 times upper limit of normal (ULN)

- Patients with measurable brain metastases according to the Response Evaluation
Criteria in Solid Tumors (RECIST) criteria

- Patients must sign an informed consent indicating that they are aware of the
investigational nature of the study

Exclusion Criteria:

- Prior brain radiation therapy

- Solitary brain metastasis according to Magnetic resonance imaging (MRI)

- Mort than 3 extracranial organs have metastatic lesions

- Prior invasive malignancy (skin basal cell cancer, carcinoma in situ of cervix are
permissible).

- pregnant or breast feeding women
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT01514877      |      Link to official Clinicaltrials.gov listing
Locations



Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2019 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557
888-295-4740