Clinical Trial Details
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NCT01808820 : Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma
PhasePhase 1
AgesMin: 13 Years Max: 99 Years
Inclusion Criteria:

1. Age: ? 13 years and ? 99 years.

2. (2a) Relapse of high grade glioma (anaplastic astrocytoma World Health Organization
(WHO) grade III or glioblastoma multiforme WHO grade IV), histologically proven at
first stage of disease (radiological evidence for recurrence suffices); OR (2b)
Relapse of glioma, which was grade II at initial diagnosis, but which is grade III or
IV at relapse based on radiological or pathological criteria.

3. Total or subtotal resection of tumor mass, confirmed by assessment by the neurosurgeon
and by postoperative MRI scan within 72 hours after surgery. The post-operative
assessment should demonstrate residual tumor less than or equal to 2 cm^3 as judged by
surgeon and on MRI the tumor should only show linear contrast enhancement at the
border of the resection cavity or nodule less than 2 cm^3.

4. No radiotherapy and/or chemotherapy received for at least 1 month before first DC
vaccination is to be administered

5. No treatment with corticosteroids or salicylates for at least 1 week before first
vaccination. Corticosteroid therapy should be rapidly weaned within 1-2 weeks after

6. Life expectancy > 3 months.

7. Written consent by patient or parent(s) (if patient is < 18 years) on an institutional
review board (IRB)-approved informed consent form prior to any study-specific
evaluation. Assent is required from children as per University of Miami (UM) IRB
guidelines. Subject must be capable of understanding the investigational nature,
potential risks and benefits of the study and able to provide valid informed consent.

8. Adequate organ function (to be measured at enrollment)

- Absolute neutrophil count (ANC) ? 0.75 10*3/µl

- Lymphocytes ? 0.5 10*3/µl

- Platelets ? 75 10*3/µl

- Hemoglobin ? 9 g/dL

- Aspartate transaminase (AST)/Alanine transaminase (ALT) ? 2.5 X upper limit of
normal (ULN); if liver metastases, ? 5 X ULN

- Serum Creatinine ? 1.5 X ULN

- Total Bilirubin ? 3 X ULN

- Albumin > 2 g/dL

9. Subjects must agree to use adequate method of contraception or abstinence throughout
and up to 4 weeks after the study treatment completion.

10. Karnofsky score 70 or higher or Eastern Cooperative Oncology Group (ECOG) status of 0
or 1.

Exclusion Criteria:

1. Pregnancy.

2. Breast feeding females.

3. Any concomitant participation in other therapeutic trials.

4. Virus serology positive for HIV (testing is not required in the absence of clinical

5. Documented immunodeficiency or autoimmune disease.

6. Mandatory treatment with corticosteroids or salicylates in the week prior to first

7. Other active malignancies.

8. Patients with unresectable tumors, for instance pontine gliomas, are excluded.

9. Refusal to use adequate contraception for fertile patients (females and males) during
the study and for 30 days after the last dose of study treatment.

10. Any serious or uncontrolled medical or psychiatric condition that in the opinion of
the investigator makes the patient not able to participate in the study.

11. Application of gliadel wafers within the prior 4 months or a plan to place gliadel
wafers at the time of resection for tumor acquisition for study.
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