Clinical Trial Details
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NCT01843413 : Stereotactic Radiosurgery in Treating Patients With Large Brain Metastases
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- Any patient undergoing SRS for brain metastases

- Lesions to be treated under this protocol must be > 2 cm, but =< 4.0 cm in diameter

- Patients may have had prior therapy including:

- Whole brain radiation therapy (WBRT) > 3 months ago

- SRS to other brain metastases

- Patients with newly diagnosed brain metastases are eligible as long as they are not
planned for WBRT upfront

- Any primary is eligible with exception of small cell lung cancer, lymphoma, and germ
cell histologies

- Patient must be able to provide written informed consent

Exclusion Criteria:

- Patients receiving SRS to resection bed

- Planned concurrent WBRT

- Leptomeningeal metastases

- Small cell lung cancer, lymphoma, and germ cell histologies

- Inability to participate in study activities due to physical or mental limitations

- Inability or unwillingness to return for all the required follow-up visits

- Conformality index 2.0 or less cannot be achieved, or homogeneity index is > 2.0

- Unable to deliver 10 Gray (Gy) or less to optic nerve/chiasm

- Brainstem location is excluded from this study
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