Clinical Trial Details
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NCT01861990 : Valproic Acid in Childhood Progressive Brain Tumors
PhasePhase 1
AgesMin: 1 Year Max: N/A
Inclusion Criteria:

- Subject, parent, or guardian willing and able to give informed consent

- Recurrent or progressive pediatric brain tumor, with MRI evidence of disease

- Age at first diagnosis of brain tumor 1-21 years old

- Lansky or Karnofsky performance score of at least 50 at diagnosis

Exclusion Criteria:

- Pregnancy

- Prior intolerance to valproic acid

- History of use of temozolomide

- Use of enzyme inducing anticonvulsant medications (see appendix B)

- Known urea cycle disorder (e.g. ornithine transcarbamylase deficiency)
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