Clinical Trial Details
Braintumor Website

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NCT02008877 : Ganetespib and Sirolimos in Patients With MPNST (Malignant Peripheral Nerve Sheath Tumors)
PhasePhase 1/Phase 2
AgesMin: 16 Years Max: N/A
Inclusion Criteria:

- Patients ? 16 years old

- Patients with unresectable or metastatic histologically confirmed sporadic or NF1
associated high grade MPNST

- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2

- Patients must have at least 1 measurable tumor

- Patients must have fully recovered from the acute toxic effects of all prior
anti-cancer therapy (toxicity < grade 2)

- Must be able to swallow whole pills

- Adequate organ function

- Normal fasting cholesterol and triglycerides

- May be on cholesterol medications

Exclusion Criteria:

- Patients receiving current treatment with corticosteroids or another
immunosuppressive. Topical or inhaled corticosteroids are allowed.

- Uncontrolled brain or leptomeningeal metastases, including patients who continue to
require glucocorticoids for brain or leptomeningeal metastases

- Symptomatic congestive heart failure

- Severely impaired lung function

- Significant vascular disease

- Uncontrolled diabetes

- Active (acute or chronic) or uncontrolled severe infections hepatitis

- Impairment of gastrointestinal function

- Patients with an active, bleeding diathesis or significant coagulopathy

- Use of cytochrome P450 isoenzyme 3A4 (CYP3A4)/ CYP2C19 substrates
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