Clinical Trial Details
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NCT02048059 : ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases
PhasePhase 2
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

1. ? 18 years old

2. Breast cancer

3. Recurrent brain metastases from breast cancer

4. At least one radiologically-confirmed and measurable metastatic brain lesion ( ? 0.5

5. Neurologically stable

6. Karnofsky Performance Status (KPS) score ? 70

Exclusion Criteria:

1. Prior treatment with ANG1005/GRN1005

2. Pregnancy or lactation

3. Inadequate bone marrow reserve

4. Any evidence of severe or uncontrolled diseases

5. Patients with the presence of an infection including abscess or fistulae, or known
infection with hepatitis B or C or HIV

6. CNS disease requiring immediate neurosurgery intervention (e.g., resection, shunt
placement, etc.)

7. Known allergy to paclitaxel or any of its components
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