Clinical Trial Details
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NCT02076711 : Myocardial Efficiency of the Left Ventricle in Asymptomatic Patients With Aortic Valve Stenosis - a Prognostic Marker and a Target for Intervention?
PhasePhase 2
AgesMin: 20 Years Max: N/A
Inclusion Criteria:

- Aortic valve area ?1,2 cm2 and/or transaortic maximal velocity (VmaxAO) of 3,0-5,0

- Sinus rhythm >60/min after 5 minutes of rest

- LVEF >?50%

- Male or female

- Age 20-100 years old

- Safe birth control management for women of childbearing potential.

- Negative urine-HCG for women of childbearing potential

- Ability to understand the written patient information and to give informed consent

Exclusion Criteria:

- Systolic BP <100 mmHg after 5 minutes of rest

- Left ventricular posterior wall thickness >17 mm

- Signs or history of major myocardial infarction and/or severe ischemic heart disease

- Severe asthma or chronic obstructive pulmonary disease

- New York Heart Association (NYHA) classification > I due to AS

- NYHA > II due to non-cardiac causes

- 2? or 3? atrioventricular block

- Ongoing beta-blocker therapy

- Ongoing verapamil or diltiazem therapy

- Ongoing monoamine oxidase inhibitors therapy (except MAO-B-inhibitors)

- Sick sinus syndrome

- Atrial fibrillation or fluttering

- Lack of stable sinus rhythm

- Pheochromocytoma

- Severe peripheral vascular disease

- Intolerance of Metoprolol succinate or its excipients

- Other disease or treatment making subject unsuitable for study participation

- Intolerance of tracer used for [11C]acetate PET recordings

- Participation in other intervention study
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