Clinical Trial Details
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NCT02082587 : Toronto BNB Pilot Study
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- Adult (> 18 years old) with newly diagnosed brain metastases planned for whole brain

- Performance status ECOG 0-2

- English-speaking (due to small sample-size in this pilot study, only English testing
will be completed)

Exclusion Criteria:

- Prior whole brain radiotherapy

- Presence of any condition which can prevent completion of neurocognitive assessment,

- Hearing impairment which is sufficient to prevent the patient from comprehending
English instructions in a quiet environment

- Major psychiatric diagnosis or neurological condition associated with cognitive
impairment which, in the judgement of the investigator, would make the patient
inappropriate for study participation (e.g., schizophrenia, multiple sclerosis,
Parkinson's disease, prior ischemic stroke, dementia, traumatic brain injury with
loss of consciousness for greater than 30 minutes, expressive/receptive aphasia,
developmental delay)

- Patients with planned systemic therapy or additional radiotherapy within the interval
between clinic and telephone Toronto BNB testing

- Minimal English skills such that subjects would be unable to follow simple English
instructions (either verbal or written) or be unable to read questionnaires of a
grade 8 standard with the help of a research assistant.
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