Clinical Trial Details
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NCT02226042 : Investigating the Mechanisms of Mindfulness-based Cognitive Therapy (MBCT)
AgesMin: 18 Years Max: 60 Years
Inclusion Criteria:

Participants with remitted depression (rMDD):

- At least two previous episodes of DSM-IV major depression in adulthood, diagnosed
using the Mini International Neuropsychiatric Interview (M.I.N.I).

- Full or partial remission for at least three months with two depressive episodes
within the last five years.

- A score of less than or equal to 12 on the Montgomery Asberg Depression Rating Scale
(MADRS) mood assessment.

- If on medication, no recent or planned major changes

Healthy volunteers:

- In good psychological health screened with the M.I.N.I

All participants:

- in good physical health (to reduce risk of confounding physical health problems).

- sufficiently fluent in English to ensure valid understanding and completion of the

- minimum I.Q level of 80 to ensure sufficient understanding of the neurocognitive
tasks administered.

- colour vision and acuity within normal/corrected to normal limits.

Exclusion criteria:

- Any current mental health diagnosis (DSM-IV diagnosis including current major
depression, bipolar disorder, psychosis, Obsessive Compulsive Disorder (OCD),
substance abuse or dependence, eating disorders)

- Physical health or neurological disorders that might interfere with the
interpretation of the tasks, including a history of significant head injury.

- In addition healthy volunteers will be without a history mental health disorders

- Current or previous experience of mindfulness-based treatments or extensive cognitive
behavioural treatment, or planned participation in psychological treatments during
the key time for the study (between pre and post visits).

- Planned major alteration in drug treatment for depression between pre and post
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