Clinical Trial Details
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NCT02272855 : A Study of Combination Treatment With HF10 and Ipilimumab in Patients With Unresectable or Metastatic Melanoma
PhasePhase 2
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

1. Patients must have Stage IIIB, IIIC or IV melanoma, which is unresectable/unresected
or histologically confirmed diagnosis of metastatic malignant melanoma.

2. Patients must have measurable non-visceral lesion(s) that are evaluable by the
modified World Health Organization (mWHO) criteria and immune-related response
criteria (irRC).

3. Patients must be ? 18 years of age.

4. Patients must have a life expectancy ? 24 weeks.

5. Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0, 1, or 2.

6. Patients must have adequate hepatic function, defined as

- Total bilirubin levels ? 1.5 x upper limit of normal [ULN] (except for patients
with Gilbert's Syndrome, who must have a total bilirubin of less than 3.0 mg/dL)

- AST/ALT levels ? 2.5 x ULN, or ? 5 x ULN if liver metastases are present.

7. Patients must have adequate renal function, defined as serum creatinine ? 1.5 x ULN
or creatinine clearance (calculated) ? 60 mL/min/1.73 m2 for patients with creatinine
> 1.5 x ULN.

8. Patients must have adequate bone marrow function, defined as

- Absolute neutrophil count ?1,500/µL and

- Platelet count ? 75,000/ µL

9. Patients must have no known bleeding diathesis or coagulopathy that would make
intratumoral injection or biopsy unsafe.

10. Patients must be ipilimumab-eligible. (This includes: 1) patients previously
untreated with ipilimumab; 2) patients previously treated (more than 1 year
previously) with ipilimumab using a route of administration other than intravenous
infusion; and 3) patients previously treated with antitumor agents other than
intravenous ipilimumab).

11. Men and women of childbearing potential must agree to use adequate contraception from
the time of consent through 30 days after final study treatment.

12. Females of childbearing potential must have a negative urine or serum pregnancy test
within one week prior to start of treatment.

13. Patients must be able to understand and willing to sign a written informed consent

Exclusion Criteria:

1. Patients receiving chemotherapy or radiotherapy within 4 weeks of injection of HF10,
or history of Grade 4 adverse events or presence of adverse events Grade 2 or
greater, except alopecia, resulting from anticancer agents administered more than 4
weeks prior to HF10 injection.

2. Patients receiving anti-herpes medication within 1 week prior to initiating HF10

3. Patients with a history of significant tumor bleeding, or coagulation or bleeding

4. Patients with target tumors that could potentially invade a major vascular structure
(e.g., innominate artery, carotid artery), based on unequivocal imaging findings.

5. Patients with Grade 2 or greater pre-existing neurologic abnormalities (CTCAE version
4.0), including Grade 2 or greater peripheral neuropathy caused by previous

6. Patients with clinically evident Human Immunodeficiency Virus (HIV), Hepatitis B
Virus (HBV), Hepatitis C virus (HCV), or Epstein-Barr virus (EBV) infection are

7. Medical history of autoimmune disease (e.g., Crohn's disease, ulcerative colitis) or
other diseases requiring systemic glucocorticoid or immunosuppressive therapy.

8. Patients who were previously treated with ipilimumab administered by intravenous

9. Concurrent use of any other investigational agents.

10. Patients with active CNS metastases or carcinomatous meningitis, except patients with
CNS lesions that have been treated and have no evidence of progression in the brain
on CT/MRI for ? 3 months.

11. Pregnant or breastfeeding women; women desiring to become pregnant within the
timeframe of the study are also excluded.

12. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements, as determined by the investigator.
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