Clinical Trial Details
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NCT02359864 : Study of Low Dose Whole Brain Irradiation in the Treatment of Alzheimer's Disease
PhasePhase 1
AgesMin: 55 Years Max: N/A
Inclusion Criteria:

Criteria for Eligibility (All responses must be YES)

1. The patient is at least 55 years old

2. The patient is able to complete the Mini-Mental Examination and ADAS-Cog score sheets

3. No previous history of CNS Radiation

4. The patient has a Rosen Modified Hachinski Ischemic Score < 4

5. Patient has estimated survival of greater than 12 months

6. Mini Mental Status Exam Score (MMSE) is 10 - 20

7. A patient with probable diagnosis of Alzheimer's disease based on NINCDS- ADRDA
criteria with MMSE scores 10 - 20

Exclusion Criteria:Criteria for Exclusion (All responses must be NO)

1. Any previous history of CNS radiation

2. The patient has a history of any oncologic disease which may mitigate the ability to
receive low dose whole brain irradiation

3. Evidence of substance abuse (alcohol/or other drugs or dependence during previous 12
months (DSM-IV criteria)

4. Presence of subdural hygroma's or subdural hematomas

5. Active / Recent (within 3 months) cerebral infection/hemorrhage

6. Immuno compromise state

7. Prior history of seizure

8. Hydrocephalus

9. Dermatological skin disease of the scalp

10. Patient taking Alzheimer's medication (Exelon, Aricept, Namenda, Reminyl

or Epixa)
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