Clinical Trial Details
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NCT02423044 : Spatial Context and Fear Learning
AgesMin: 18 Years Max: 50 Years

- Ages 18-50

- Subjects able to give their consent

- Right handed

- Patients only: a primary diagnosis of GAD, panic disorder, SAD, or PTSD according to
the Structured Clinical Interview for DSM-IV-TR


- Non-English speaking individual

- Any significant medical or neurological problems (e.g. cardiovascular illness,
respiratory illness, neurological illness, seizure, etc.)

- High or low blood pressure (SBP> 140 or SBP< 90; SDP< 50 or SDP> 90)

- Alcohol/drug abuse in the past year or lifetime alcohol or drug dependence according
to the Structured Clinical Interview for DSM-IV-TR

- Medications that act on the central nervous system (e.g., Lorazepam, Codeine) and
thus may interfere with the interpretation of study results. Specific exclusionary
drug classes include but are not limited to: (opioid analgesics, DA receptor
agonists, anticholinergics, MAO inhibitors, COMT inhibitors, as well as any illicit

- Pregnancy or positive pregnancy test

- Neurological syndrome of the wrist (e.g., carpal tunnel syndrome, cubital tunnel
syndrome, etc.)

- Positive urine toxicology screen

- IQ < 80

- Participants who report getting severe motion sickness, especially by playing video

- Any medical condition that increases risk for fMRI:

- Any metal implants (clips, screws, plates, pins, etc) or metal fragments cause
by injuries or metal working

- Any sort of medical implants (aneurysm clips, pacemaker, insulin pump, Hickman
line, etc.)

- Permanent eye liner and tattoos above the neck

- Patients who have difficulty lying flat on their back for up to 60 min in the

- Participants who are uncomfortable in small closed spaces (have claustrophobia)
and would feel uncomfortable in the MRI machine

Additional Exclusion Criteria for Healthy Volunteers:

- Current or past Axis I psychiatric disorders as identified with the Structured
Clinical Interview for DSM-IV-TR, non-patient edition (SCID-np)

- Current use of psychotropic medications (i.e. fluoxetine (Prozac), fluvoxamine
(Luvox), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa) or escitalopram
(Lexapro), etc.).

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Additional Exclusion Criteria for Patients:

- Patients who are currently on psychotropic medications. (Patients are required to be
free of all psychotropics medication (i.e. fluvoxamine (Luvox), sertraline (Zoloft),
paroxetine (Paxil), citalopram (Celexa) or escitalopram (Lexapro), etc.) for 2 weeks,
5 weeks for fluoxetine prior to testing. Patients will not be taken off medications
for the purpose of the study)

- Patients will be excluded if they have a current or past history of any psychotic
disorder, delirium, dementia, amnestic disorder, cognitive disorder not otherwise
specified, any of the pervasive developmental disorders, or mental retardation

- Patients who have a primary diagnosis of major depressive disorder.
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