Clinical Trial Details
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NCT02429570 : Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary
AgesMin: 18 Years Max: 80 Years
Inclusion Criteria:

- Age 18-80

- KPS ? 60

- At least one recurrent or progressive brain metastasis (es) from any solid primary
tumor that is visible on MRI as assessed by the patient's treating physician.

- Recurrence may occur after any treatment: recurrence after whole-brain radiation,
stereotactic radiosurgery, surgical resection, systemic chemotherapy are all

- There is no limit on the number of brain metastases.

- Surgical resection or SRS to other recurrent lesions in the same patient are
acceptable, provided one recurrent lesion remains untreated.

- Systemic disease must be well-controlled or NED in the opinion of the patient's
primary oncologist.

Exclusion Criteria:

- Inability to get brain MRI +/- contrast

- Progressive systemic disease

- Known leptomeningeal metastases

- Primary Brain tumor

- Active Intracranial Hemorrhage

- Surgery less than two weeks before enrollment

- GI hemorrhage (active or in recent 6 months)

- Concurrent anti-platelet therapy

- Concurrent anti-coagulation therapy

- Active bleeding diathesis

- Platelet count ? 70,000/mm3

- International normalized ratio (INR) > 1.6 and a Partial Thromboplastin Time (PTT) >
40 seconds

- Serum Creatinine >2 mg/dL OR CrCL <30ml/min

- AST or ALT > 200 U/L

- Hemoglobin <8 g/dL

- Allergy to meclofenamate or other NSAID

- Inability to tolerate PO dosing

- Steroid dose increased in the most recent two weeks.

- Pregnancy

- Cardiac Arrhythmia requiring medical management and/or pacemaker.

- Known congestive heart failure requiring medical management
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