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|NCT02530320 : Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved|
|Ages||Min: 18 Years Max: N/A|
1. Ability to understand and sign the informed consent approved by the Ethic Committee.
2. Men or women aged greater than or equal to 18.
3. Patients with oligodendroglioma anaplastic or oligoastrocytoma anaplastic according to
WHO classification and histologically confirmed. Note: It can be included patients
with oligoastrocytoma or oligodendroglioma G2 only if they have suffered a recurrence
in which the diagnosis of the resection were G3.
4. Patients in relapse after radiotherapy and one or two lines of chemotherapy. Note:
Both previous radiotherapy and chemotherapy could be received in adjuvant therapy or
previous recurrences. It is also accepted to be received concurrent chemoradiotherapy.
In the secondary oligodendrogliomas or oligoastrocytomas anaplastic, the patients
could have received chemotherapy and radiotherapy when the tumor was G2.
5. All patients have to present positivity in immunohistochemical study for the RB
protein in the tumor samples sent to the central lab.
6. The cases must have 10 slides or a tumor block available from a biopsy or surgery.
7. All patients have to show disease progression in a cerebral nuclear magnetic
8. Interval of at least one week between the previous intracranial biopsy and the
9. Interval of at least 12 weeks between radiotherapy and the inclusion, unless: a)
Recurrent tumor confirmed histologically b) recurrency showed in the NMR out of
10. Patients should have been recovered from previous therapies: 28 days since the end of
any investigational product and since the end of any cytotoxic treatment.
12. Stable or decreasing dose of corticoids during the five days prior to the inclusion
13. patients who have been suffered from a tumor resection in the last recurrence are
- A good surgery recover
- there is a measurable or evaluable disease after surgery
14. Good bone marrow function:
- Neutrophils = 1500/mm3 (1.5x10e9/L)
- Platelet = 100.000/mm3 (100 x 10e9)
- Hemoglobin = 9 g/dL
- Seric creatinine = 1.5 x LSN of the site or estimated clearance = 60 ml/min
- Bilirubin = 1.5 x LSN (if Gilbert's syndrome = 3 xLSN) AST (SGOT) and/or ALT = 3
x LSN; alkaline phosphatase = 2.5 x LSN.
15. Nor pregnant women nor breast-feeding women. Women with heterosexual activity should
have a negative pregnant test before the inclusion in the study. Both women and men
should use an accepted contraceptive method during the study treatment and 1 month
after treatment completed.
1. Presence of meningeal carcinomatosis disseminated.
2. Concomitant treatment with other investigational products
3. Previous treatment wih an investigational product that could be active for CDK4/6
4. Any kind of surgery in the previous 2 weeks
5. Presence of any clinically significant gastrointestinal abnormality that can affect
oral administration, transit or absorption of study drug, such as the inability to
take medication by mouth as tablets.
6. Presence of any psychiatric or cognitive disorder that limits the understanding or the
signature of informed consent and / or jeopardize the fulfillment of the requirements
of this protocol.
7. In the 7 days prior to the beginning of the treatment, to have received a treatment
with: - Drugs inhibitor of the CYP3A4 - Drugs inductors of the CYP3A4 - Drugs that
extends the QT interval
8. QTc interval >480 msec, familiar history or personal of QT large Syndrome, QT short
Syndrome, Brugada syndrome, QTc extension or Torsade de Pointes history
9. Electrolyte disorder that may affect the QTc interval
10. Significant or uncontrolled cardiovascular disease, including:
- Myocardial infarction within the previous 12 months
- Uncontrolled angina within the previous 6 months
- Congestive heart failure in the previous 6 months
- History of clinically significant ventricular arrhythmias of any type (as
ventricular tachycardia, ventricular fibrillation or torsades de pointes)
- History of second or third grade heart block (these patients may be eligible if
you currently have a pacemaker)
- Pulmonary embolism
11. History of any cancer, except for the following circumstances:
- Patients with a history of other malignancies are eligible if they have been free
of disease for at least the last 3 years, and at the discretion of the
investigator, there is low risk of disease recurrence.
- Patients with the following cancers are eligible even if they are diagnosed and
treated in the last 3 years: carcinoma in situ of the cervix and basal cell or
basal cell skin carcinoma. Patients are ineligible if there is evidence of any
neoplastic disease that required therapy other than surgery in the past 3 years.
12. Patients positive for HIV
13. Inflammatory bowel disease, chronic diarrhea, short gut syndrome or any upper
gastrointestinal surgery including gastric resection.
14. History of allergic reactions to Palbociclib
15. Another acute or chronic serious medical condition, uncontrolled intercurrent illness
or laboratory abnormality that may increase the risk associated with trial
participation or investigational product administration or may interfere with the
interpretation of test results and that,investigator's discretion, make the patient
inappropriate for entry into this trial. Uncontrolled intercurrent illness including,
but are not limited to, ongoing or active infection or psychiatric illness / social
situations that limit the compliance of study requirements.
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