Clinical Trial Details
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NCT02530658 : Next Generation Sequencing of Tumor and Normal Tissues Prospectively in Pediatric Oncology Patients at St. Jude Children's Research Hospital
AgesMin: N/A Max: N/A
Inclusion Criteria:

- New St. Jude patients prospectively identified at the time of study activation with:

- Newly diagnosed solid or liquid tumor (benign or malignant),

- Relapsed solid or liquid tumor (benign or malignant), or

- Refractory solid or liquid tumor (benign or malignant)

- Current St. Jude patients who develop a new mass and undergo a surgical procedure to
establish the diagnosis of recurrent disease or a new primary tumor.

- Current St. Jude patients who, while on therapy, develop refractory disease and
undergo a surgical procedure to palliate symptoms.

- Adequate tissue must be available (e.g. sufficient germline and/or tumor tissue, from
which >1 µg DNA and >0.1 µg RNA must be isolated). Patients with retinoblastoma,
diffuse intrinsic pontine glioma, craniopharyngioma, or optic pathway tumors who have
no tumor tissue available may enroll using only a germline sample.

Exclusion Criteria:

- Past history of hematopoietic stem cell transplantation (or other condition that
would result in hematopoietic cell DNA failing to match host tissue DNA).

- Tumor or germline tissue not meeting the criteria listed above.

- Inability or unwillingness of research participant or legal guardian/representative
to give written informed consent.

- Participants who are unable to read, write or converse fluently in English will be
excluded from Prespecified Objectives 3 and 4.
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