Clinical Trial Details
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NCT02594800 : Intensive Rosuvastatin Therapy on Cerebral Hemodynamics in Patients With Atherosclerotic Intracranial Arterial Stenosis
PhasePhase 4
AgesMin: 18 Years Max: 80 Years
Inclusion Criteria:

1. Provision of informed consent

2. Male and female adults aged 18-80years old

3. Recent (within 3 months) ischemic stroke or TIA;

4. Intracranial large artery (intracranial internal artery, middle cerebral artery M1,
vertebral artery and basilar artery) stenosis between 50-99%.

5. Statin naïve:defined as receiving no statin therapy within 3 months

Exclusion Criteria:

1. Cardioembolic stroke;

2. Rosuvastatin use is contraindicated;

3. Allergic to contrast agents;

4. Chronic devastating illness, multiple organ failure;

5. Dementia or mental disorder unable to return for repeat brain CTP.

6. Administration of lipid-lowering drugs (statin, clofibrate, probucol or analog,
nicotinic acid, or other prohibited drug) before enrollment.

7. Active liver disease or aminopherase ?3 ULN(Upper Limit of Normal)

8. Renal function damage. GFR?Glomerular Filtration Rate? ?30ml/min
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