Clinical Trial Details
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NCT02639767 : Concurrent Pemetrexed/Cisplatin With Pleural Intensity Modulated Radiation Therapy for Patients With Unresectable Malignant Pleural Mesothelioma
PhasePhase 1
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- Pathologically confirmed diagnosis of malignant pleural mesothelioma at MSKCC

- No plans for surgical resection

- Stage T1-4, N0-3, M0

- No prior radiation therapy to the chest, breast or supraclavicular fossa that would
limit radiation delivery to the full prescription dose

- Prior chemotherapy regimens ?1

- Age ?18 years

- Karnofsky performance status ? 80%

- Pulmonary function tests as follows: DLCO>50% predicted

- Adequate hematologic, hepatic, and renal function as indicated by the following
laboratory values

- Absolute neutrophil count ? 1,500/mcL

- Platelets ? 100,000/mcL

- Calculated creatinine clearance (CrCl) ? 45mL/min (using Cockcroft & Gault

- Serum total bilirubin ? 1.5 x upper limit of normal (ULN) (unless known
Gilbert's disease)

- AST (SGOT) and ALT (SGPT) ? 3.0 x ULN

Exclusion Criteria:

- Pregnant or lactating women, or men or women not using effective contraception

- Patients with an active infection that requires systemic antibiotics, antiviral, or
antifungal treatments

- Patients with a concurrent active malignancy (with the exception of skin cancer)

- Patients with serious unstable medical illness

- Patients with idiopathic pulmonary fibrosis

- Patients with NYHA heart failure class >2

- Patients with only one kidney that is ipsilateral to the mesothelioma

- Implanted pacemaker and/or defibrillator ipsilateral to the mesothelioma if it cannot
be moved
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