Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02639767 : Concurrent Pemetrexed/Cisplatin With Pleural Intensity Modulated Radiation Therapy for Patients With Unresectable Malignant Pleural Mesothelioma
PhasePhase 1
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

- Pathologically confirmed diagnosis of malignant pleural mesothelioma at MSKCC

- No plans for surgical resection

- Stage T1-4, N0-3, M0

- No prior radiation therapy to the chest, breast or supraclavicular fossa that would
limit radiation delivery to the full prescription dose

- Prior chemotherapy regimens ?1

- Age ?18 years

- Karnofsky performance status ? 80%

- Pulmonary function tests as follows: DLCO>50% predicted

- Adequate hematologic, hepatic, and renal function as indicated by the following
laboratory values

- Absolute neutrophil count ? 1,500/mcL

- Platelets ? 100,000/mcL

- Calculated creatinine clearance (CrCl) ? 45mL/min (using Cockcroft & Gault
method)

- Serum total bilirubin ? 1.5 x upper limit of normal (ULN) (unless known
Gilbert's disease)

- AST (SGOT) and ALT (SGPT) ? 3.0 x ULN

Exclusion Criteria:

- Pregnant or lactating women, or men or women not using effective contraception

- Patients with an active infection that requires systemic antibiotics, antiviral, or
antifungal treatments

- Patients with a concurrent active malignancy (with the exception of skin cancer)

- Patients with serious unstable medical illness

- Patients with idiopathic pulmonary fibrosis

- Patients with NYHA heart failure class >2

- Patients with only one kidney that is ipsilateral to the mesothelioma

- Implanted pacemaker and/or defibrillator ipsilateral to the mesothelioma if it cannot
be moved
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT02639767      |      Link to official Clinicaltrials.gov listing
Locations



Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2019 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557
888-295-4740