Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02684071 : Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors
PhasePhase 2
AgesMin: N/A Max: 22 Years
Eligibility
Inclusion Criteria:

- Recurrent or progressive supratentorial or posterior fossa tumors with measurable
disease on imaging studies of the brain and spine or CSF cytology.

- Tumor histology, including: Medulloblastoma , PNET, or other embryonal tumor, Atypical
teratoid/rhaboid tumor (AT/RT), and Ependymoma.

- Leptomeningeal dissemination of a previously diagnosed CNS tumor.

- Diagnosis of tumor pathology will be based upon pathology diagnosis from previous
surgeries for patients with recurrent tumors.

- Patients must have received prior radiation before current recurrence, unless the
patient is less than 36 months old at diagnosis and has progressed after at least one
upfront chemotherapy regimen in which case no prior radiation is required.

- Patients must have a life expectancy of at least 12 weeks as indicated by the
patient's oncologist and/or neurosurgeon.

- Lansky or Karnofsky Performance status of at least 50.

- Negative pregnancy test.

- Specific organ function requirements for: Central Nervous System, Bone Marrow, renal
and liver.

Exclusion Criteria:

- Patients that do not meet the inclusion criteria above.

- Pregnant or lactating female patients.

- Patients currently enrolled in another experimental treatment protocol.

- Patients with documented allergies to any of the chemotherapy agents used in this
study.

- Patient/Parent refuses study participation.

- Patient is severely somnolent or comatose.

- Unable or unwilling to commit to return or to follow-up visits.
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT02684071      |      Link to official Clinicaltrials.gov listing
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