Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02713984 : A Clinical Research of CAR T Cells Targeting HER2 Positive Cancer
PhasePhase 1/Phase 2
AgesMin: 18 Years Max: 80 Years
Eligibility
Inclusion Criteria:

1. Relapsed or refractory HER2 positive cancer.

2. KPS>60.

3. Life expectancy>3 months.

4. Gender unlimited, age from 18 years to 80 years.

5. Assessable lesions with a minimum size of 10mm by CT scan or MRI.

6. Acceptable organ function

Hematology:

- Absolute neutrophil count greater than 800/mm^3 without the support of
filgrastim.

- White blood cell (WBC) (> 2000/mm^3).

- Platelet count greater than 50,000/mm^3.

- Hemoglobin greater than 9.0 g/dl.

Chemistry:

- Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less or
equal to 3 times the upper limit of normal (patients without liver metastasis)
or 6 times the upper limit of normal (patients with liver metastasis).

- Serum creatinine less or equal to 3 times the upper limit of normal

- Total bilirubin less than or equal to 3 times the upper limit of normal.

7. No other serious diseases(autoimmune disease, immunodeficiency etc.).

8. Adequate cardiac function(LVEF?40%).

9. No other tumors.

10. Patients volunteer to participate in the research.

Exclusion Criteria:

1. Allergic to cytokines.

2. Uncontrolled active infection.

3. Acute or chronic GVHD.

4. MODS.

5. Treated with T cell inhibitor.

6. HIV affected.

7. Other situations improper for the research.
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT02713984      |      Link to official Clinicaltrials.gov listing
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