Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02722512 : Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine
PhasePhase 1
AgesMin: 3 Years Max: 21 Years
Eligibility
Inclusion Criteria:

- Arm A: Newly Diagnosed High Grade Glioma Tumor

- Arm B: Recurrent, resectable High Grade Glioma or Ependymoma

- Stable Neurologic Status

- Lanksy/Karnofsky score greater than or equal to 50.

- Adequate Bone Marrow Function (ANC= 1000/µL, platelets= 100,000/µL transfusion
independent, Hemoglobin = 8.0 gm/dL with or without transfusion support)

- Adequate Liver Function (Bilirubin = 2x institutional normal for age, Alanine
transaminase (ALT) = 5x institutional normal for age, Aspartate Aminotransferase (AST)
= 5x institutional normal for age)

- Adequate Renal Function (Normal creatinine for age and/or glomerular filtration rate =
70 mls/min/1.73 m2)

- Female patients of childbearing potential must have a negative serum or urine
pregnancy test

Exclusion Criteria:

- Patients with unresectable disease are not eligible.

- Patients with primary spinal cord tumors are not eligible.

- Patients with metastatic disease are not eligible for Arm A (this does NOT apply to
Arm B).

- Patients with a known allergy to any component of the vaccine or any compounds of
similar chemical or biologic composition of the vaccine are not eligible.

- Patients with known auto-immune disease are excluded.

- Patients with known immunodeficiency are excluded.

- Patients with a concurrent malignancy are excluded.

- Clinically Significant Concurrent Illness

- Patients receiving any other anticancer or investigational drug

- Patients with uncontrolled seizure disorders

- Patients whose central nervous system (CNS) tumor is considered a secondary malignancy
from prior therapies
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT02722512      |      Link to official Clinicaltrials.gov listing
Locations



Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2019 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557
888-295-4740