Clinical Trial Details
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NCT02750059 : Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis
PhasePhase 2
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

1. Age ? 18 years old

2. Have protocol-defined acute HIV-1 infection (Tested 4th generation HIV enzyme
immunoassay [EIA] negative and NAT positive or tested 4th generation HIV EIA
positive, negative by less sensitive EIA and nucleic acid testing [NAT] positive)

3. Be part of the SEARCH 010/RV 254 study

4. Ability and willingness to start ART immediately after diagnosis

5. Understand the study and sign informed consent form. Persons who cannot read will
have the consent form read to them by a member of the study staff and may then give
informed consent by using making a thumb print

6. Availability for follow-up for the duration of the planned study

7. Systolic blood pressure ? 110 mmHg

8. Agree to undergo lumbar puncture at weeks 0, 48 and 72

9. Ability and willingness to provide informed consent

Exclusion Criteria:

1. Pregnancy (current or within the last 6 months) or breastfeeding

2. Uncontrolled hypertension

3. Use of thiazolidinediones or other angiotensin receptor blockers class [losartan,
irbesartan, olmesartan, valsartan, candesartan (washout permitted)]

4. Screening laboratory values: absolute neutrophil count (ANC) < 750 cells/mm3,
hemoglobin <10 gm/dL creatinine clearance<30mL/min (estimated by the Cockcroft-Gault
equation using ideal body weight)

5. Known renal artery stenosis

6. Known cirrhosis or severe liver disease

7. Unstable coronary artery disease/angina or decompensated congestive heart failure

8. Any history of intolerance to any angiotensin II receptor blocker (ARB)

9. Need for ongoing potassium supplementation

10. Any contraindication to lumbar puncture such as history of bleeding diathesis or
known cerebral mass lesion
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