Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02766270 : CCRT With Temozolomide Versus RT Alone in Patients With IDH Wild-type/TERT Promoter Mutation Grade II/III Gliomas
PhaseEarly Phase 1
AgesMin: 18 Years Max: 70 Years
Eligibility
Inclusion Criteria:

- Histologically confirmed supratentorial Diffuse low-grade and intermediate-grade
gliomas (World Health Organization grades II and III )

- IDH wild-type and TERT promoter mutation

- Age > 18

- Karnofsky performance score > 60

- Neutrophilic granulocyte count > 1500/µl

- Platelet count > 100 000/µl

- Hemoglobin > 10 g/dl

- Serum creatinine < 1.5 times the lab's upper normal limit

- AST or ALT < 1.5 times the lab's upper normal limit

- Adequate medical health to participate in this study

- No previous systemic chemotherapy

- No previous radiotherapy to the brain

- Written informed consent

Exclusion Criteria:

- Serious medical or neurological condition with a poor prognosis

- Contraindications to radiotherapy or temozolomide chemotherapy

- Patient unable to follow procedures, visits, examinations described in the study

- Second cancer requiring radiotherapy or chemotherapy

- Inability to undergo gadolinium-contrasted MRIs

- Pregnant women or nursing mothers can not participate in the study
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT02766270      |      Link to official Clinicaltrials.gov listing
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