Clinical Trial Details
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NCT02781792 : Temozolomide Chronotherapy for High Grade Glioma
PhasePhase 1
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- Newly diagnosed and recurrent high grade gliomas (WHO grades III & IV) and high risk
WHO grade II gliomas who are to begin treatment with monthly high dose temozolomide

- Scheduled to receive adjuvant temozolomide therapy after having completed concurrent
temozolomide and radiation therapy.

- At least 18 years of age.

- Karnofsky performance status = 60%

- Ability to understand and willingness to sign an IRB approved written informed consent

Exclusion Criteria:.

-Pregnant and/or breastfeeding. Women of childbearing potential must have a negative
pregnancy test within 14 days of study entry.
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