Clinical Trial Details
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NCT02798003 : Food Reward in Cachexia Induced by Acute or Chronic Disease
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- For cachectic patients: weight loss exceeds 5% of total body weight over the past 6
months, or >2% when body mass index is <20 kg/m2

- For non-cachectic patients: no weight loss of ?5% during the last 6 months

- Non-small cell lung cancer or gastro-intestinal cancer, pathology proven or diagnosis
of COPD consistent with the Global Initiative for Chronic Obstructive Lung Disease
(GOLD) criteria

Exclusion Criteria:

- Contra-indications for fMRI examination (operation to your head or brain in the past;
implanted electronic devices, for instance a pacemaker, neurostimulator, cochlear or
hearing implant; insulin pump under your skin; Pregnant subjects, claustrophobia;
pregnancy; metal parts in your body (except from teeth filling and connectors):
implants; brain vessel clamps, prostheses, intra-uterine device, metal splinter in
the eye, metal braces or other metal objects, permanent eye make-up)

- Psychiatric or other disorders likely to impact on informed consent

- Presence of brain metastasis (screening is not mandatory)

- Medical history of cerebrovascular accident, brain tumour, brain metastasis

- Previous radiotherapy to brain, both stereotactic and whole brain radiotherapy

- Memory problems

- Current use of tube feeding or parental nutrition

- Patients with an active second malignancy

- Patients unable to lie still for 2 hours

- Unable to complete the cognitive task

- Pre-existing swallowing difficulties

- Allergy to gluten-, milk- or wheat products

- Self-reported hyperthyroidism

- Self-reported diabetes mellitus

- Current use of appetite stimulant medications
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