Clinical Trial Details
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NCT02906631 : Epidemiology and Prognosis of Encephalitis in Intensive Care
AgesMin: 18 Years Max: N/A
Inclusion criteria:

- Altered mental status, delirium, or personality changes for a duration > or = 24 h

- At least 2 of the following: 1) fever (>38°C) within 72 hours before or following
hospital admission; 2) new-onset seizures; 3) new-onset focal signs; 4) CSF
pleocytosis > 5 cell / microl; 5) brain parenchyma abnormalities on neuroimaging
compatible with the diagnosis of encephalitis; 6) EEG abnormalities compatible with
the diagnosis of encephalitis.

- Altered mental status with a GCS < or =13 without sedation, or GCS < or =13 before
sedation administration in sedated patients

- CSF analysis performed

- Brain imaging performed (CT/MRI)

- Age >18

Exclusion criteria:

- Time between the first hospitalization for neurologic symptoms in relation with
encephalitis and ICU admission > 7 days

- Purulent bacterial meningitis diagnosed by direct examination or CSF analysis

- Isolated brain abscess.

- Febrile encephalopathy associated with another diagnosis

- Predicted time in ICU < or = 24 hours

- Opposition of close-of-kin, if present at the inclusion, for patient participation in
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