Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02928692 : Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
PhasePhase 3
AgesMin: 65 Years Max: N/A
Eligibility
For the placebo and minocycline group;

Inclusion Criteria:

1. Elder than 65 years old

2. Speak Chinese Mandarin

3. Those who will undergo major general surgery like colorectal cancer excision, major
urinary surgery like radical prostatectomy and radical nephrectomy

4. Signed the inform consent

5. American Society of Anesthesiologists classification I to III

Exclusion Criteria:

1. Existing cerebral disease, or have a history of neurological and psychiatric diseases
including Alzheimer Disease, stroke, epilepsy and psychosis;

2. Existing cognitive impairment as evidenced by Mini-Mental State Examination scores
below 24;

3. Severe audition or vision disorder;

4. Unwillingness to comply with the protocol or procedures.

5. Cannot communicated with Chinese Mandarin

6. With severe skin disease

7. Serious heart or liver or renal insufficiency patients

8. Had surgery in the past 30 days

9. Allergy to tetracycline or minocycline

For the health volunteers;

Inclusion Criteria:

1. Elder than 65 years old

2. Speak Chinese Mandarin

3. Signed the inform consent

4. No major disease health people

Exclusion Criteria:

1. Existing cerebral disease, or have a history of neurological and psychiatric diseases
including Alzheimer Disease, stroke, epilepsy and psychosis;

2. Existing cognitive impairment as evidenced by Mini-Mental State Examination scores
below 24;

3. Severe audition or vision disorder;

4. Unwillingness to comply with the protocol or procedures.

5. Cannot communicated with Chinese Mandarin

6. Drug abuse, alcoholism

7. Serious heart or liver or renal insufficiency patients

8. Had surgery in the past 30 days

9. Plan to undergo surgery in the following 3 months.
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT02928692      |      Link to official Clinicaltrials.gov listing
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