Clinical Trial Details
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NCT02953756 : Cognitive Outcome After Gamma Knife Radiosurgery in Patients With Brain Metastases (CAR-Study A)
AgesMin: 18 Years Max: N/A
Inclusion Criteria:

- Histologically proven malignant cancer

- 1-10 newly diagnosed brain metastases on a triple dose gadolinium-enhanced MRI-scan

- Maximum total tumor volume 30 cm3

- Lesion ? 3 mm from the optic apparatus

- Age ? 18 years

- Karnofsky Performance Status (KPS) ? 70

- Anticipated survival > 3 months

Exclusion Criteria:

- No prior histologic confirmation of malignancy

- Primary brain tumor

- A second active primary tumor

- Small cell lung cancer

- Lymphoma

- Leukemia

- Meningeal disease

- Progressive, symptomatic systemic disease without further treatment options

- Prior brain radiation

- Prior surgical resection of brain metastases

- Additional history of a significant neurological or psychiatric disorder

- Participation in a concurrent study in which neuropsychological testing and/or
health-related QOL assessments are involved

- Contra indications to MRI or gadolinium contrast

- Underlying medical condition precluding adequate follow-up

- Lack of basic proficiency in Dutch

- IQ below 85

- Severe aphasia

- Paralysis grade 0-3 according to MRC scale (Medical Research Council)
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