Clinical Trial Details
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NCT03027544 : Tomotherapy for Refractory Brain Metastases
AgesMin: 18 Years Max: 75 Years
Inclusion Criteria:

- Histologic or cytologic diagnosis of primary tumor and conformed brain metastases by
enhanced MRI or CT; the lesion number is no less than 3; or the tumor volume is no
smaller than 6cc; or tumor diameter is no shorter than 3cm; or uncontrolled brain
tumor after whole brain radiotherapy(WBRT); or the tumor is adjacent to essential
structures of the brain, such as brain stem, optic chiasma, optic tract, etc; KPS
=60,or KPS =40 and the limitation of motion is simply caused by brain tumor that is
adjacent to the motor function areas; Age: 18-75 years old;

Adequate end-organ function:

WBC=4.0x109/L Neu = 1.5x109/L Hemoglobin = 110 g/L Platelets =100 x109/L Total bilirubin =
1.5x ULN AST and ALT = 1.5x ULN BUN and Cr: within the normal range.

Exclusion Criteria:

- • Other clinically significant diseases (e.g.myocardial infarction within the past 6
months, severe arrhythmia).

- Unable or unwilling to comply with the study protocol.

- The expected survival time is less than 3 months.

- Patients who are anticipated in other clinical trials of brain metastases.

- Patients who has been treated with SRT in other hospitals

- Pregnant patients or female patients whose HCG is positive

- Unsuitable to participate in study, that in the opinion of the treating
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