Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT03035851 : Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias
PhaseN/A
AgesMin: 50 Years Max: 80 Years
Eligibility
Inclusion Criteria:

- inactive men and women aged 50-80 years (inclusive) with subjective cognitive symptoms
but no dementia who have one or more vascular risk factors (see below) for ADRD;

- Inactivity will be assessed with a physical activity questionnaire and defined as
engagement in <3 sessions/week of 20 min or more of vigorous exercise;

- Subjective cognitive symptoms will be self-reported using the MAC-Q Memory Complaint
Questionnaire, recently validated as a measure of subjective memory complaints in
healthy elderly subjects, in patients with mild cognitive impairment, and in relation
to AD biomarkers; participants with a score of ?25 will be considered eligible.

- Vascular risk factors for ADRD including the following:

- history of hypertension;

- diabetes mellitus;

- obesity (body mass index (BMI) <40 kg/m2)

- elevated cholesterol;

- currently smoking;

- past history of coronary artery disease without recent (<5 years) symptoms.

Participants must provide a completed PAR-Q+ form (www.csep.ca), the standard method of
obtaining physician approval for participation in an exercise program. For participants
without a family doctor to provide this form, we will provide information on how to find a
family doctor.

Exclusion Criteria:

- diagnosis of a developmental handicap;

- history of dementia (DSM-V criteria)**;

- terminal illness (life expectancy < 1 year)

- not fluent in verbal and written English;

- history of stroke;

- currently participating in another trial;

- comorbid medical or neurological illnesses (e.g., multiple sclerosis) that would
confound cognitive assessments or make trial completion unlikely (in the site
investigator's opinion);

- contraindication for the intervention;

- contraindication for an MRI exam.

- **Existing or suspected dementia will be identified by medical history, cognitive
impairment on the Telephone Interview for Cognitive Status (TICS-modified; score? 20),
or impaired Instrumental Activities of Daily Living (IADL) - a response of needs
assistance or dependent due to cognitive impairments on any item on the Lawton scale.
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT03035851      |      Link to official Clinicaltrials.gov listing
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