Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT03042156 : Immunotherapy And Palliative Radiotherapy Combined In Patients With Advanced Malignancy
PhaseN/A
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

1. Adults aged 18 years or older

2. Histologically or cytologically confirmed solid tumor malignancy

3. Advanced disease (locally advanced and/or metastatic)

4. Life expectancy > 3 months

5. Patients planned to receive palliative radiotherapy (including whole liver
radiotherapy)

6. Patients who are already on or about to commence a checkpoint inhibitor

7. Measurable disease according to irRECIST on CT or MRI

8. ECOG performance status 0-2

9. Able to provide informed consent

10. Able to complete telephone/email communication

11. Additional criteria for subset of patients for abscopal analysis (to be done post
hoc):

1. Measurable disease outside irradiated volume

2. Must be on same checkpoint inhibitor/immunotherapy (or same class of checkpoint
inhibitor) for 3 months prior to radiotherapy and have stable disease or
oligoprogression in past 3 months

3. Availability of prior biopsy specimen (preferably fresh frozen tissue) for
research and genotyping

Exclusion Criteria:

1. Medical conditions which may be contraindications to radiotherapy

2. Any medical or non-medical issue that would affect the patient's ability to provide
informed consent for study participation, or would interfere with the patient's
treatment on study.
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT03042156      |      Link to official Clinicaltrials.gov listing
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