Clinical Trial Details
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NCT03141619 : Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2
AgesMin: 18 Years Max: N/A

1. Adults ? 18 years old

2. Admitted to a critical care unit requiring one or more of the following:

(a) Respiratory failure requiring invasive mechanical ventilation with an expected
duration >24 hours (b) Shock of any etiology. Shock is defined by the need for one of
the following vasopressors/inotropes: (i) Dopamine ?7.5 mcg/kg/min (ii) Dobutamine ?5
mcg/kg/min (iii) Norepinephrine ?5 mcg/min (iv) Phenylephrine ?75 mcg/min (v)
Epinephrine at any dose (vi) Milrinone at any dose (if used in conjunction with
another agent) (vii) Vasopressin ?0.03 u/min(if used in conjunction with another


1. Admission to the ICU > 24 hours

2. Life expectancy <24 hours

3. Admitting diagnosis that affects the central nervous system

4. Any reason that the subject may not be able to participate in the follow up
assessments (i.e. limb amputation, paresis, neuromuscular disorders)
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