Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT03343197 : Study of AG-120 and AG-881 in Subjects With Low Grade Glioma
PhasePhase 1
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

1. Be =18 years of age.

2. Have histologically or cytologically confirmed recurrent Grade 2 or 3 LGG
(oligodendroglioma or astrocytoma according to World Health Organization 2016
classification).

3. Have documented IDH1 R132H gene mutation by local testing and known 1p19q or ATRX
mutation status by local testing.

4. Have central confirmation of primarily non-enhancing disease by MRI with less than or
equal to 5 mm slice thickness and up to 1 mm interslice gap on either 2D T2 weighted
image, 3D T2 weighted image, or FLAIR, with at least 1 non-enhancing tumor measuring
1×1×1 cm.

5. Be candidates for clinical resection but for whom surgery is not urgently indicated
(eg, for whom surgery within the next 2-4 months is appropriate).

6. Have KPS of =60%

7. Have expected survival of =12 months.

Exclusion Criteria:

1. Have received prior systemic anti-cancer therapy within 1 month of the first dose of
AG-120 or AG-881 or have received an investigational agent <14 days prior to their
first dose of AG-120 or AG-881. In addition, the first dose of AG-120 or AG-881 should
not occur before a period of =5 half-lives of the investigational agent has elapsed.

2. Have had radiation within 6 months of the first dose of AG-120 or AG-881. (Note: Prior
biopsy or surgery is allowed.)

3. Have received any prior treatment with an IDH inhibitor.

4. Have received any prior treatment with bevacizumab (Avastin).
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT03343197      |      Link to official Clinicaltrials.gov listing
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