Clinical Trial Details
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[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT03373370 : Early Diagnosis of TTR Amyloidosis by Use of Molecular Biology
PhaseN/A
AgesMin: 51 Years Max: N/A
Eligibility
Inclusion Criteria:

- A. Adult (>50 yo)

- Chronic Peripheral neuropathies (progressing since 12 months),

- Peripheral neuropathies documentated by ENMG.

1. Chronic polyneuropathy with dysautonomia (orthostatic hypotension) without
diabetes

2. Atypical CIDP (situations C, D (even with high protid content on CSF) & E as
defined by the French group for study of CIDP).

3. Disabling neuropathy (gait or balance disorder)

4. Neuropathies with upper limb onset who underwent previously CTS surgery without
success.

5. SLA-like syndrome : areflexia with sensory alterations on ENMG. 6: Deterioration
of SNAPs' amplitudes on NCS > 30% in less than6 months by the same NCS laboratory
Mandatory : A+B+C one of 1 to 6

Exclusion criteria :

- Amyloid deposit characterized on biopsy

- Causes of chronic polyneuropathy : Diabetes mellitus, Chronic alcoholic intoxication

- CIDP responding to IVIg or corticosteroids (improvement by 1 point of ONLS).

- Neuropathy associated with monoclonal gammapathy and i) anti-MAG activity or ii) POEMS
syndrome or) CANOMAD syndrome.

- Ataxic Neuropathy due to vitamine B12 deficiency

- Ataxic Neuropathy due to IgM anti-MAG,

- CANOMAD syndrome,

- Ganglionopathy by Sjögren's syndrome, or paraneoplastic syndrome with Anti- Hu
Antibodies, chemotherapy induced (cis-platine, oxaliplatine).

- Positive family history of FAP or FAC

- Proven AL amyloidosis

Exclusion Criteria:
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT03373370      |      Link to official Clinicaltrials.gov listing
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