Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT03428009 : Dystonia Genotype-Phenotype Correlation
Phase
AgesMin: 11 Years Max: N/A
Eligibility
General Exclusion (both Dystonia and Control groups):

- Metal in any part of the body (including metal injury to the eye) OR carrying a
medical device incompatible with MRI (e.g., metal implants such as surgical clips or
pacemakers) OR positive screening per UTSW MRI screening form

- Claustrophobia

- Non-fluent English

- Weight incompatible with MRI safety

- History of head trauma with neurological sequelae, including multiple concussions
and/or history of stroke

- Pregnancy

- Serious medical illness or history of serious medical illness, including cancer that
was treated with radiation or chemotherapy, heart attack, or a known history of HIV-1
+ status

- Subjects with Hepatitis C (by Hepatitis C+ titer)

- Subjects with insulin dependent diabetes mellitus (IDDM)

- Severe respiratory compromise

- In the opinion of the investigator, not able to safely participate in this study

Inclusion Criteria:

- Dystonia group

Previous diagnosis of dystonia which include but is not limited to:

- cervical dystonia (50 subjects)

- blepharospasm (25 subjects)

- limb dystonia (50 subjects)

- spasmodic dysphonia (25 subjects)

- segmental dystonia

- multi-focal dystonia

- Any childhood-onset dystonia (25 subjects) Age > 11 years

- Control group:

No prior dystonia diagnosis (175 subjects) Age > 11 years

Exclusion Criteria:

- Dystonia group Prior history of or concurrent neurological or psychiatric diagnosis -
depression and/or anxiety accepted Current use of non-dystonia neuroactive medications
- SSRI/medication for depression and/or anxiety accepted Current use of cervical brace
designed for dystonia treatment Prior structural brain injury

Control group:

History of or current neurological or psychiatric diagnosis - depression and/or anxiety
accepted, but must not be in active phase Current use of any neuroactive medication,
SSRI/medication for depression and/or anxiety accepted
LinksPermanent Link to THIS page: https://virtualtrials.com/nct/display1trial.cfm?nct=NCT03428009      |      Link to official Clinicaltrials.gov listing
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