Clinical Trial Details
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NCT03508752 : Neurocognitive Decline in Patients With Brain Metastases
PhasePhase 1/Phase 2
AgesMin: 18 Years Max: 120 Years
Inclusion Criteria:

- Age = 18 years.

- ECOG Performance Score of 2 or better.

- Biopsy-proven non-hematopoietic malignancy, except for germ cell cancer. Small cell
lung carcinoma is eligible for this study

- Six or more metastases on diagnostic or treatment planning imaging, which include
either CT or MR imaging.

- Largest tumor <4 cm

- No prior SRS to the lesions which will be treated on protocol.

- Women of child-bearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry, and
for the duration of protocol treatment.

- Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

- Prior whole brain radiotherapy

- Patients with leptomeningeal metastasis.

- Patients with life expectancy < 4 months

- Psychiatric illness/social situations that would limit compliance with study
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