Clinical Trial Details
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NCT03639896 : Endothelial Injury Mechanism of in Elderly Patients Undergoing Major Surgery
AgesMin: 65 Years Max: 90 Years
Inclusion Criteria:

1. Written informed consent;

2. Patients undergoing selective major noncardiac surgery and general anesthesia;

3. Age 65-90 yrs;

4. Anesthesia Society of American (ASA) Scale II~III;

5. Anticipated surgery time 2-6 hrs;

Exclusion Criteria:

1. Dementia patients(Mini-mental state examination< 20)

2. Factors existed that affect cognition assessment such as language,visual,and auditory

3. Unstable metal status and mental disease;

4. The cognitive function examination in 3-6 months is not anticipated to be completed

5. Patients undergoing cardiac and neural surgery;

6. Parkinson's Disease;

7. Sure or suspected abuse of analgesic and sedation drug.
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