Brain Tumor Related News!
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Brain Tumor Conferences / Events
New Clinical Trials
Noteworthy Treatments Explanation of the new high tech treatments!
Conferences / Events
UCLA 17th Annual Brain Tumor Conference
- Dates: March 10-11, 2017
- Location: UCLA Carnesale Commons, 251 Charles E. Young Drive West, 3rd Floor, Los Angeles, CA 90095
- Contact: Luzianne Fernandez
- Phone: (310) 206-3610
- Email Address: mailto:firstname.lastname@example.org
- Online Registration: www.neurooncology.ucla.edu
- Join brain tumor survivors, families, caregivers, and healthcare professionals at the 17th Annual UCLA Brain Tumor Conference, hosted by the UCLA Brain Tumor Center. This free conference will offer participants the opportunity to hear leading healthcare professionals speak about the latest treatments for brain tumors, symptom management, community resources and social support.
- Educational sessional will cover topics such as in-depth information on tumors types, neurosurgery, radiation therapy, chemotherapy, updates in experimental treatments, nutrition, neuropsychology and brain tumors, clinical trials, symptom management, psycho-social support, creative arts therapies, navigating health insurance, end of life issues, and much more.
Brain Tumor News!
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02/22/17 UPDATED: Agenus’ lead cancer vaccine flops, investigators read last rites over glioblastoma PhII
Unfortunately, this trial failed. It may have failed because the vaccine was started too late - at the time of recurrence. It makes a lot more sense to try it for newly diagnosed healthier patients. Adding in a checkpoint inhibitor should also help. Lastly, with other vaccines, the early readings of the trial did not look good, but as time goes on, there was a small group of patients who do well for a much longer time than expected.
02/04/17 New Brain Cancer Coalition Announces Precision Medicine Study During CHOP Event
I love collaborations like this. It will help speed up the search for the cure. An interesting part of this is that Independent Blue Cross will pay for the genomic testing of the patients for their patients. Cost was a big stumbling block for some similar projects.
The Musella Foundation helped fund some of the early work on this!
01/25/17 Combination therapy for glioblastoma shows promising results in early-stage research
This project is funded, in part, by the Musella Foundation!
It shows that that the vaccine can be enhanced significantly by using other immune modulating drugs. The full text of the article is not available for free, only the abstract is free. The full text shows how strong the effect is when using each treatment separately, then in all combinations. It is a major improvement.
This project also shows, I think for the first time, that the immune suppression caused by PD-L1 is created by tumor-infiltrating myeloid cells and not directly by the tumor cells, which is what I always assumed. The huge significance of this is that doing a biopsy of a tumor and testing for PD-L1 on the tumor cells shouldn't make any difference to how the treatment would work.
I would love to see this being done in humans.
01/25/17 Antiangiogenic treatments prolong OS in glioblastoma subgroup
This is exciting. They found that Avastin can more than double the survival for patients who have highly vascularized tumors. The test they use - perfusion MRI is readily available. This shows how antiquated our clinical trial system is. It is going to be very hard to find a single treatment that cures everyone. Until we find that, we have to use what we have. That is many treatments that each help a small group tremendously, helps a little in a larger group, and not at all in others. Avastin failed when they did a trial mixing all patients. The best way to have run the trial is to test early to see how the treatment is doing, and figure out which subgroups benefit and which do not. At that point, they should stop accruing patients that they know will not do well - let them try other trials. But we are not doing that now. (There is some work going on to try this - called adaptive trial design - but it is not widespread). Obviously, the best way is to get as many of these treatments approved so we can use them in rational combinations. Figure out which treatments will help YOUR particular tumor, and combine the few that look best.
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